Engerix-B 10 (Pediatric)
Engerix-B 10 (Pediatric) is a vaccine used to protect infants and children up to 15 years of age against hepatitis B, a viral infection that affects the liver. This vaccine is specifically formulated with a lower antigen content suitable for the pediatric population.

Pharmaceutical Properties
Engerix-B 10 Pediatric contains the recombinant hepatitis B surface antigen (HBsAg) produced in yeast cells using recombinant DNA technology.

Each 0.5 mL dose contains:

• 10 micrograms of HBsAg

• Aluminum hydroxide adjuvant to boost immune response

The vaccine is sterile, non-infectious, and free from blood products. It is administered intramuscularly, typically in the anterolateral thigh for infants or the deltoid muscle for older children.

Indications for Use
Engerix-B 10 Pediatric is indicated for:

• Active immunization against hepatitis B virus (HBV) in infants, children, and adolescents up to 15 years of age

• Infants born to HBV-positive mothers

• Children in high-risk environments, such as those in healthcare settings or traveling to areas with high HBV prevalence

It may also be used for catch-up immunization in children who missed doses during infancy.

Mechanism of Action
The vaccine introduces a harmless piece of the hepatitis B virus (the surface antigen) into the body. This stimulates the immune system to recognize it as foreign and develop protective antibodies.

If the child is later exposed to the real virus, the immune system is already prepared to neutralize it quickly, preventing infection and liver damage. Engerix-B does not contain live virus, so it cannot cause the disease.

Clinical Protocol in Dubai
In Dubai, the pediatric vaccination schedule for hepatitis B typically includes Engerix-B 10 Pediatric as part of the national immunization program. The standard schedule is:

• First dose: At birth

• Second dose: At 1 month of age

• Third dose: At 6 months of age

In some cases, a four-dose schedule may be used for infants born to HBV-positive mothers or under specific clinical recommendations. The vaccine can be given alone or in combination with other pediatric vaccines.

Other Characteristics
Engerix-B 10 Pediatric is generally safe and well tolerated. Common side effects include:

• Mild pain, redness, or swelling at the injection site

• Low-grade fever

• Fatigue or irritability

Severe allergic reactions are very rare. The vaccine is non-infectious, contains no preservatives, and is suitable for use in immunocompromised children under medical guidance.

Conclusion
Engerix-B 10 Pediatric is a vital vaccine that protects children from hepatitis B, a potentially lifelong liver infection. Given early in life and on schedule, it helps establish strong and lasting immunity. In Dubai, this vaccine is part of the standard pediatric immunization plan, ensuring children are protected from an early age. Parents should follow the recommended schedule and consult with pediatricians for any personalized medical advice.